Announcement PDF 603 page 1/2 15 July 2001 Form 603 Corporations Act 2001 Section 671B Notice of initial substantial holder To Company Name/Scheme Neuren Pharmaceuticals Limited ACN/ARSN 111 496 130 1. Details of substantial holder (1) Name ACN/ARSN (if applicable) Vanguard Group (The Vanguard Group, Inc. and its controlled entities including those listed in Annexure A) N/A The holder became a substantial holder on 19 February 2025 2. Details of voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in on the date the substantial holder became a substantial holder are as follows: Class of securities (4) Ordinary Number of securities 6,503,840 Person’s votes (5) 6,503,840 Voting power (6) 5.000% 3. Details of relevant interests The nature of the relevant interest the substantial holder or an associate had in the following voting securities on the date the substantial holder became a substantial holder are as follows: Holder of relevant interest Vanguard Group Nature of relevant interest (7) Vanguard Group is the manager of various Mutual funds and accounts and in that capacity has the power to dispose of the shares. The other members of Vanguard Group have a relevant interest under section 608(3) of the Corporations Act. Class and number of securities Ordinary – 6,503,840 4. Details of present registered holders The persons registered as holders of the securities referred to in paragraph 3 above are as follows: Holder of relevant interest Vanguard Group Registered holder of securities Brown Brothers Harriman Person entitled to be registered as holder (8) Various funds and other accounts of Vanguard Group Class and number of securities Ordinary – 82,960 Vanguard Group BNY Mellon Various funds and other accounts of Vanguard Group Ordinary – 506,825 Vanguard Group JP Morgan Chase Bank, N.A. Various funds and other accounts of Vanguard Group Ordinary – 4,857,089 Vanguard Group State Street Bank and Trust Company Various funds and other accounts of Vanguard Group Ordinary – 1,056,966 5. Consideration The consideration paid for each relevant interest referred to in paragraph 3 above, and acquired in the four months prior to the day that the substantial holder became a substantial holder is as follows: Holder of relevant interest Date of acquisition Consideration (9) See Annexure A External Use Authorized Class and number of securities 603 page 2/2 6. Associates The reasons the persons named in paragraph 3 above are associates of the substantial holder are as follows: Name and ACN/ARSN (if applicable) Nature of association N/A N/A 7. Addresses The addresses of persons named in this form are as follows: Name Vanguard Group Address P.O. Box 2600, V26 Valley Forge, PA 19482 USA print name Shawn Acker sign here capacity date External Use Authorized Compliance Manager 24 February 2025 15 July 2001 DIRECTIONS (1) If there are a number of substantial holders with similar or related interests (eg. a corporation and its related corporations, or the manager and trustee of an equity trust), the names could be included in an annexure to the form. If the relevant interests of a group of persons are essentially similar, they may be referred to throughout the form as a specifically named group if the membership of each group, with the names and addresses of members is clearly set out in paragraph 7 of the form. (2) See the definition of “associate” in section 9 of the Corporations Act 2001. (3) See the definition of “relevant interest” in sections 608 and 671B(7) of the Corporations Act 2001. (4) The voting shares of a company constitute one class unless divided into separate classes. (5) The total number of votes attached to all the voting shares in the company or voting interests in the scheme (if any) that the person or an Associate has a relevant interest in. (6) The person’s votes divided by the total votes in the body corporate or scheme multiplied by 100. (7) Include details of: (a) any relevant agreement or other circumstances by which the relevant interest was acquired. If subsection 671B(4) applies, a copy of any document setting out the terms of any relevant agreement, and a statement by the person giving full and accurate details of any contract, scheme or arrangement, must accompany this form, together with a written statement certifying this contract, scheme or arrangement; and (b) any qualification of the power of a person to exercise, control the exercise of, or influence the exercise of, the voting powers or disposal of the securities to which the relevant interest relates (indicating clearly the particular securities to which the qualification applies). See the definition of “relevant agreement” in section 9 of the Corporations Act 2001. (8) If the substantial holder is unable to determine the identity of the person (eg. if the relevant interest arises because of an option) write “unknown”. (9) Details of the consideration must include any and all benefits, moneys and other, that any person from whom a relevant interest has acquired has, or may, become entitled to receive in relation to that acquisition. Details must be included even if the benefit is conditional on the happening or not of a contingency. Details must be included of any benefit paid on behalf of the substantial holder of its associate in relation to the acquisitions, even if they are not paid directly to the person from whom the relevant interest was acquired. External Use Authorized Annexure A To Company ACN/ARSN Neuren Pharmaceuticals Limited 111 496 130 Substantial Holder Name ACN/ARSN Vanguard Group N/A Date of change Nature of Change(6) BUY BUY BUY BUY BUY BUY SELL BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY SELL SELL BUY BUY SELL BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY SELL BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY Person whose relevant interest changed 13-Nov-2024 The Vanguard Group, Inc. 3-Dec-2024 The Vanguard Group, Inc. 3-Dec-2024 The Vanguard Group, Inc. 5-Dec-2024 The Vanguard Group, Inc. 6-Dec-2024 The Vanguard Group, Inc. 11-Dec-2024 The Vanguard Group, Inc. 20-Dec-2024 The Vanguard Group, Inc. 7-Jan-2025 The Vanguard Group, Inc. 31-Jan-2025 The Vanguard Group, Inc. 6-Feb-2025 The Vanguard Group, Inc. 19-Feb-2025 The Vanguard Group, Inc. 21-Oct-2024 Vanguard Investments Australia Ltd. 22-Oct-2024 Vanguard Investments Australia Ltd. 22-Oct-2024 Vanguard Investments Australia Ltd. 23-Oct-2024 Vanguard Investments Australia Ltd. 24-Oct-2024 Vanguard Investments Australia Ltd. 25-Oct-2024 Vanguard Investments Australia Ltd. 25-Oct-2024 Vanguard Investments Australia Ltd. 28-Oct-2024 Vanguard Investments Australia Ltd. 28-Oct-2024 Vanguard Investments Australia Ltd. 29-Oct-2024 Vanguard Investments Australia Ltd. 30-Oct-2024 Vanguard Investments Australia Ltd. 30-Oct-2024 Vanguard Investments Australia Ltd. 30-Oct-2024 Vanguard Investments Australia Ltd. 31-Oct-2024 Vanguard Investments Australia Ltd. 1-Nov-2024 Vanguard Investments Australia Ltd. 1-Nov-2024 Vanguard Investments Australia Ltd. 5-Nov-2024 Vanguard Investments Australia Ltd. 5-Nov-2024 Vanguard Investments Australia Ltd. 6-Nov-2024 Vanguard Investments Australia Ltd. 8-Nov-2024 Vanguard Investments Australia Ltd. 11-Nov-2024 Vanguard Investments Australia Ltd. 12-Nov-2024 Vanguard Investments Australia Ltd. 13-Nov-2024 Vanguard Investments Australia Ltd. 20-Nov-2024 Vanguard Investments Australia Ltd. 25-Nov-2024 Vanguard Investments Australia Ltd. 26-Nov-2024 Vanguard Investments Australia Ltd. 26-Nov-2024 Vanguard Investments Australia Ltd. 28-Nov-2024 Vanguard Investments Australia Ltd. 28-Nov-2024 Vanguard Investments Australia Ltd. 2-Dec-2024 Vanguard Investments Australia Ltd. 5-Dec-2024 Vanguard Investments Australia Ltd. 9-Dec-2024 Vanguard Investments Australia Ltd. 10-Dec-2024 Vanguard Investments Australia Ltd. 13-Dec-2024 Vanguard Investments Australia Ltd. 17-Dec-2024 Vanguard Investments Australia Ltd. 19-Dec-2024 Vanguard Investments Australia Ltd. 19-Dec-2024 Vanguard Investments Australia Ltd. 19-Dec-2024 Vanguard Investments Australia Ltd. 20-Dec-2024 Vanguard Investments Australia Ltd. 20-Dec-2024 Vanguard Investments Australia Ltd. 23-Dec-2024 Vanguard Investments Australia Ltd. 24-Dec-2024 Vanguard Investments Australia Ltd. 24-Dec-2024 Vanguard Investments Australia Ltd. 27-Dec-2024 Vanguard Investments Australia Ltd. 31-Dec-2024 Vanguard Investments Australia Ltd. 2-Jan-2025 Vanguard Investments Australia Ltd. 3-Jan-2025 Vanguard Investments Australia Ltd. 6-Jan-2025 Vanguard Investments Australia Ltd. 8-Jan-2025 Vanguard Investments Australia Ltd. 10-Jan-2025 Vanguard Investments Australia Ltd. 13-Jan-2025 Vanguard Investments Australia Ltd. 13-Jan-2025 Vanguard Investments Australia Ltd. 15-Jan-2025 Vanguard Investments Australia Ltd. 17-Jan-2025 Vanguard Investments Australia Ltd. 20-Jan-2025 Vanguard Investments Australia Ltd. 21-Jan-2025 Vanguard Investments Australia Ltd. 23-Jan-2025 Vanguard Investments Australia Ltd. # External Use Authorized Consideration given in relation to change(7) Class 16.54 Ordinary 13.09 Ordinary 13.35 Ordinary 12.74 Ordinary 12.80 Ordinary 13.47 Ordinary 12.14 Ordinary 12.12 Ordinary 14.49 Ordinary 13.93 Ordinary 13.52 Ordinary 12.91 Ordinary 12.55 Ordinary 12.55 Ordinary 12.78 Ordinary 12.45 Ordinary 12.47 Ordinary 12.47 Ordinary 12.61 Ordinary 12.61 Ordinary 12.33 Ordinary 12.28 Ordinary 12.28 Ordinary 12.28 Ordinary 12.35 Ordinary 12.25 Ordinary 12.25 Ordinary 12.27 Ordinary 12.27 Ordinary 13.27 Ordinary 16.57 Ordinary 16.33 Ordinary 17.03 Ordinary 16.54 Ordinary 13.69 Ordinary 12.66 Ordinary 12.32 Ordinary 12.32 Ordinary 12.63 Ordinary 12.63 Ordinary 12.69 Ordinary 12.76 Ordinary 12.74 Ordinary 12.97 Ordinary 13.32 Ordinary 13.16 Ordinary 12.54 Ordinary 12.54 Ordinary 12.54 Ordinary 12.14 Ordinary 12.14 Ordinary 12.21 Ordinary 12.20 Ordinary 12.20 Ordinary 12.34 Ordinary 12.50 Ordinary 12.25 Ordinary 12.20 Ordinary 12.01 Ordinary 12.46 Ordinary 11.91 Ordinary 11.85 Ordinary 11.85 Ordinary 11.01 Ordinary 13.20 Ordinary 12.90 Ordinary 13.60 Ordinary 14.55 Ordinary Number of securities Person's votes affected affected 9,458 9,458 18,552 18,552 1,064 1,064 2,124 2,124 138 138 18,208 18,208 (12,492) (12,492) 13,211 13,211 223 223 121 121 17,721 17,721 1,236 1,236 118 118 2,360 2,360 412 412 824 824 1,170 1,170 819 819 1,392 1,392 1,392 1,392 812 812 115 115 345 345 575 575 154 154 1,710 1,710 684 684 1,236 1,236 1,648 1,648 1,344 1,344 1,665 1,665 2,616 2,616 1,239 1,239 1,199 1,199 824 824 (18,858) (18,858) (6,912) (6,912) 1,536 1,536 1,568 1,568 (15,015) (15,015) 1,243 1,243 1,155 1,155 1,368 1,368 456 456 565 565 452 452 678 678 2,260 2,260 28,137 28,137 11,790 11,790 12,492 12,492 113 113 904 904 1,130 1,130 385 385 (3,850) (3,850) 218 218 777 777 1,332 1,332 666 666 1,665 1,665 666 666 377 377 440 440 1,320 1,320 436 436 436 436 440 440 Annexure A Date of change Nature of Change(6) BUY BUY BUY BUY BUY BUY BUY BUY BUY SELL BUY BUY BUY BUY BUY BUY BUY Person whose relevant interest changed 24-Jan-2025 Vanguard Investments Australia Ltd. 24-Jan-2025 Vanguard Investments Australia Ltd. 28-Jan-2025 Vanguard Investments Australia Ltd. 28-Jan-2025 Vanguard Investments Australia Ltd. 30-Jan-2025 Vanguard Investments Australia Ltd. 3-Feb-2025 Vanguard Investments Australia Ltd. 4-Feb-2025 Vanguard Investments Australia Ltd. 6-Feb-2025 Vanguard Investments Australia Ltd. 6-Feb-2025 Vanguard Investments Australia Ltd. 6-Feb-2025 Vanguard Investments Australia Ltd. 10-Feb-2025 Vanguard Investments Australia Ltd. 11-Feb-2025 Vanguard Investments Australia Ltd. 12-Feb-2025 Vanguard Investments Australia Ltd. 12-Feb-2025 Vanguard Investments Australia Ltd. 17-Feb-2025 Vanguard Investments Australia Ltd. 18-Feb-2025 Vanguard Investments Australia Ltd. 18-Feb-2025 Vanguard Investments Australia Ltd. This is Annexure A of 2 pages referred to in Form 603, Notice of initial substantial holder. Signature: Name: Shawn Acker Capacity: Compliance Manager Date: 24 February 2025 # External Use Authorized Consideration given in relation to change(7) Class 14.73 Ordinary 14.73 Ordinary 14.39 Ordinary 14.39 Ordinary 14.45 Ordinary 13.67 Ordinary 13.18 Ordinary 13.93 Ordinary 13.93 Ordinary 13.93 Ordinary 13.72 Ordinary 13.31 Ordinary 13.05 Ordinary 13.05 Ordinary 13.30 Ordinary 13.07 Ordinary 13.07 Ordinary Number of securities Person's votes affected affected 1,320 1,320 154 154 1,650 1,650 770 770 333 333 336 336 1,904 1,904 1,017 1,017 1,695 1,695 (1,131) (1,131) 336 336 2,128 2,128 565 565 231 231 5,866 5,866 2,340 2,340 2,340 2,340