The Neuren team is far from complacent following the success of the last two years. We are acutely aware that it follows, and has been built on, a ten-year journey since our first clinical trial in Rett syndrome and that many loyal and committed shareholders have accompanied us on that journey. The experience we have gained on the ten-year journey is extremely valuable. Everything we have learnt from the development of trofinetide in Rett syndrome is directly relevant to our development of NNZ-2591 in other neurodevelopmental disorders, led by Phelan-McDermid syndrome. We believe that this and the connection of both drugs to IGF-1 enhances the risk profile of the NNZ-2591 programs. There is so much more to achieve and 2024 is another very important year for the business. We look forward to the continued progress of DAYBUE, both in the US and in other territories. We await the results of the Phase 2 trials of NNZ2591 for Pitt Hopkins syndrome in Q2 2024 and for Angelman syndrome in Q3 2024. In the meantime, the team is highly focused on advancing the Phelan-McDermid syndrome program. We are diligently preparing for an End of Phase 2 Meeting with the FDA and are commencing manufacture of the drug supplies that will be required for a Phase 3 program. We are also actively exploring further potential indications for NNZ-2591 and will say more about this as our assessment progresses. Patrick Davies Chair Jon Pilcher CEO CHAIR AND CEO MESSAGE CONTINUED Neuren is in a very strong financial position, with cash and short-term investments of more than A$200 million and the ongoing revenues from DAYBUE. This supports our commitment to achieving the best outcome for shareholders by pursuing value-adding opportunities to their fullest potential. For NNZ-2591, we will continue to evaluate all options to achieve this as the events of this year unfold. We are grateful to our shareholders, both longstanding and new, and all the patient communities for the support that is so critical for our success. We commend and thank the Neuren team for their achievements and dedication, assisted by a range of development partners. NEUREN’S VALUES We are passionate about making a difference to the lives of patients and their families We aim to earn the respect of everyone we deal with We are determined and creative to break through barriers We recognise the importance of all stakeholders and endeavour to use financial resources efficiently We harness the power of collaboration and different perspectives Neuren Pharmaceuticals Limited Annual Report 2023 3
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